A Brief History
Humans have cultivated and consumed the flowering tops of female cannabis plants since virtually the beginning of recorded history. Cannabis-based textiles dating to 7,000 B.C. have been recovered in northern China, and the plant's use as a medicinal and euphoric agent date back nearly as far. In 2008, archeologists in Central Asia discovered over two pounds of cannabis in the 2,700-year-old grave of an ancient mummified shaman. After scientists conducted extensive testing on the material's potency, they affirmed, The most probable conclusion ... is that ancient cultures cultivated cannabis for pharmaceutical, psychoactive, and divinatory purposes.
Modern cultures continue to utilize cannabis for these same purposes, despite a present-day, nearly worldwide ban on the plant's cultivation and consumption imposed by various governments. In the United States, Congress initially imposed federal prohibitions outlawing cannabis' recreational, industrial, and therapeutic use by the passage of the Marihuana Tax Act of 1937. This federal prohibition was later reaffirmed by Congress' decision to classify marijuana - as well as all of the plant's active compounds, known as cannabinoids - as Schedule I substances under the Controlled Substances Act of 1970.
Despite the U.S. government's nearly century-long prohibition of the plant, scientists in America and around the world have continued to closely study the plant and its effects on living organisms, including in clinical trials. In recent years, scientists' interest in the plant and its active constituents, known as cannabinoids, has increased exponentially. Scientific study of the cannabis plant has now identified over 60 unique, biologically active cannabinoids - such as THC, THCV, CBD, THCA, CBC, and CBG, among others - many of which possess documented therapeutic properties. A recent meta-analysis of these compounds identifies well over a dozen therapeutic properties attributable to cannabinoids, including neuroprotective, anti-cancer, anti-bacterial, and anti-diabetic properties. To date, there are over 22,000 published studies or reviews in the scientific literature pertaining to the cannabis plant and its cannabinoids.
The many uses of this Multi-Faceted Plant
Historically, humans have used various parts of the cannabis plant for a multitude of purposes. Most people today are readily aware that cannabis is consumed socially as a mood-enhancer. By contrast, certain varieties of cannabis - as well as most parts of the plant, including the seeds and the stalk - contain virtually no psychoactive properties but may be utilized in other ways. For example, ground seeds from the cannabis plant contain high and balanced levels of essential amino acids and essential fatty acids and may be baked into a variety of nutritional food-stuffs. Oil can also be processed from cannabis seeds and consumed as a nutritional supplement
The stalk of the marijuana plant, primarily of the cannabis sativa variety - which can grow as high as 20 feet in height - can also be harvested for it’s fiber content. This renewable resource is a common source of paper, rope, clothing, and building materials. Most industrialized nations, including Canada, Japan, Australia, and the European Union, regulate the commercial production of low THC varieties of cannabis for industrial purposes. During World War II the U.S. government commissioned tens of thousands of domestic farmers to grow cannabis to assist with America's wartime needs. Following the War's conclusion, however, the United State's government imposed a complete ban on the domestic production of the plant, including the cultivation of non-psychoactive cannabis sativa varieties.
The plant's cannabinoids are largely responsible for cannabis' physiological, mood-altering, and therapeutic effects. THC, the most studied of all the plant's cannabinoids, is psychoactive and is primarily responsible for the plant's influence on mood and behavior. It also possesses various therapeutic effects. Most acknowledged among these are pain relief, appetite stimulation, nausea and vomiting mitigation, anti-spasticity and anti-spasmodic effects, and intraocular pressure reduction in patients with glaucoma. A number of additional, non-psychotropic cannabinoids such as CBD also possess numerous therapeutic properties.
How it Interacts with the Body
Scientists are only recently beginning to understand the many complex ways that cannabinoids interact with the human body. Subjects experience psychological and physiological effects after ingesting cannabis because cannabinoids, THC in particular, interact with a complex and dense receptor system within the body.
The CB1 receptors, first identified in the late 1980s, reside predominantly in the nervous system and their stimulation is responsible for the plant's psychoactive and behavioral effects, among other functions. The CB2 receptors, identified in the early 1990s, reside primarily in the immune system and are involved in the moderation of a number of biological functions, including inflammation and pain response. Naturally occurring chemicals in human body (called endocannabinoids), which possess a similar molecular structure to herbal cannabinoids, act as neuromodulators and cytokine modulators within this receptor system to regulate many of the body's essential physiological functions -- including appetite, blood pressure, reproduction, bone growth, tumor modulation, immunity, inflammation, pain sensation, memory, and muscle tone, among others.
It is theorized that a properly functioning endogenous cannabinoid receptor system is necessary for good health and that certain disease types may be the result of deficiencies within this system. According to a National Institutes of Health review, "Modulating the activity of the endocannabinoid system ... holds therapeutic promise in a wide range of disparate diseases and pathological conditions, ranging from mood and anxiety disorders, movement disorders such as Parkinson's and Huntington's disease, neuropathic pain, multiple sclerosis and spinal cord injury, to cancer, atherosclerosis, myocardial infarction, stroke, hyper- tension, glaucoma, obesity/metabolic syndrome, and osteoporosis, to name just a few."